Curcumin mitigates axonal injury and neuronal cell apoptosis through the PERK/Nrf2 signaling pathway following diffuse axonal injury
نویسندگان
چکیده
منابع مشابه
Protection of FK506 against neuronal apoptosis and axonal injury following experimental diffuse axonal injury
Diffuse axonal injury (DAI) is the most common and significant pathological features of traumatic brain injury (TBI). However, there are still no effective drugs to combat the formation and progression of DAI in affected individuals. FK506, also known as tacrolimus, is an immunosuppressive drug, which is widely used in transplantation medicine for the reduction of allograft rejection. Previous ...
متن کاملInflammatory Response Following Diffuse Axonal Injury
DAI is a leading cause of the patient's death or lasting vegetable state following severe TBI, and up to now the detailed mechanism of axonal injury after head trauma is still unclear. Inflammatory responses have been proved to be an important mechanism of neural injury after TBI. However, most of these studies are concerned with focal cerebral injury following head trauma. In contrast to focal...
متن کامل8-hydroxy-2-(di-n-propylamino)tetralin intervenes with neural cell apoptosis following diffuse axonal injury★
Previous studies have reported a neuroprotective effect of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) against traumatic brain injury. In accordance with the Marmarou method, rat models of diffuse axonal injury were established. 8-OH-DPAT was intraperitoneally injected into model rats. 8-OH-DPAT treated rats maintained at constant temperature served as normal temperature controls. TUNEL ...
متن کاملAssociation Between Serum Electrolyte Disturbances and Glasgow Coma Scale Score in Patients With Diffuse Axonal Injury
Background: Appropriate clinical measures to prevent secondary brain damage in traumatic brain injury are of critical importance. Objectives: This study aims to investigate the relationships between serum electrolyte disturbances and Glasgow Coma Scale (GCS) score in patients with Diffuse Axonal Injury (DAI) at the time of admission and discharge. Materials & Methods: In this retrospective cr...
متن کاملDiffuse Axonal Injury: Pathological and Clinical Aspects
Diffuse traumatic brain injury refers to widespread pattern of injury throughout the brain caused by traumatic disruption of nerve cells, with particular injury to the axons [1]. There are four principal types of traumatic brain injury: diffuse vascular injury, diffuse axonal injury, hypoxic-ischemic encephalopathy and diffuse brain swelling [2]. Clinically, DAI is characterized by generalized ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: NeuroReport
سال: 2018
ISSN: 0959-4965
DOI: 10.1097/wnr.0000000000001015